Reghecampf started his managerial career at Liga II team FC Snagov, in 2009. At the end of 2009–10 season, he was brought at Universitatea Craiova to save the team from relegation. He ended his quest successfully, but he was not kept at Craiova for the new season.
Reghecampf then joined Gloria Bistrita where he worked with the team for 12 games. Reghecampf returned to Snagov, but after only five games he was called back to Craiova.

He started the 2011–12 season at FC Snagov, for a third spell. Every time Reghecampf came back to FC Snagov, he found the team on the latest places and he managed to bring them if front of the leaderboard.

In December 2011 he signed a contract with Romanian Liga I club Concordia Chiajna, with a difficult objective, avoiding relegation, the team placing only 17th after half a season. He changed almost the entire squad, bringing 17 new players, most of them from Snagov, and after a series of wins, finished the season on the 9th place. In this second half of the season, Concordia Chiajna was actually the best Romanian team, winning 35 points in only 16 matches.

This evolution brought the attention of his former team, Steaua Bucharest, and at the end of the season, they offered him a contract.

His objective – bringing the first championship title for Steaua after seven years. In May 2013 he mathematically won the Romanian League after only 29 rounds and later the Romanian Supercup. Aslo, he guided the club into the UEFA Europa League round of 16 and took them into the UEFA Champions League group stage at the start of 2013/14. Another important aspect is that in 2012-2013 season, Steaua had 79 points, with 16 points more that the team from the 2nd place and in 2013-2014 season Steaua achieved a total of 77 points, with 9 points more that the next team.

On 9 May 2014, Steaua with manager Laurențiu Reghecampf at the helm won their second consecutive league title. Reghecampf also lead his side to the Romanian Cup final.

" I managed to achieve something important at Steaua, but at the moment I don't think I'm capable of finding that little bit more to motivate the players," was the reaction of Reghecampf when leaving Steaua, who suffered only four defeats in 68 league games at the helm. " I did nothing but perform at this club and that's what I want to stay in the memory of our fans. We achieved fantastic things together. "

On 27 May 2014, he signed a contract with Al-Hilal, Saudi Arabia. Since Reghecampf's arrival, Al Hilal edged past Qatar's Al Sadd 1-0 on aggregate in the ACL quarterfinals before the romp against Al Ain, making it eight successive clean sheets in the competition.

Reghecampf was considered one of the emerging European coaching stars in Saudi Arabia, who has a great name in Romania for his outstanding technical style, when he led the Romanian team Steaua București to achieve the League's title after six years of lacking, achieving the leagues of the seasons 2012-2013 and 2013-2014, in addition to the Romanian Supercup 2013, to be named as the Best Coach of Romania 2 years in a row.

He led Al-Hilal to the AFC Champions League five months after his appointment, by defeating Al-Ain 4–2 in semi-finals.

He is currently head coach of the Bulgarian team PFC Litex Lovech.

Awards:
- Excellence award for coaching in 2015